FIG. 5.

Cidofovir treatment leads to clearance of γHV68 antigen and amelioration of pathology. Shown is a plot of lesion severity scores, as described in Table 1, as a function of time of death or sacrifice. Only mice with lesions are represented. The presence or absence of viral antigen (Ag) in lesions was assessed by immunohistochemistry as described in Materials and Methods (Ag staining). Weeks p.i., time postinfection of death or sacrifice. Since there were no differences in lesion severity for viral antigen-positive lesions of mice that died or were sacrificed 4 to 8 weeks postinfection, these data were pooled in columns 1 and 2. Mice in columns 3, 4, and 5 were all sacrificed. ∗, P < 0.0001 compared to scores for PBS-treated mice. ∗∗, P = 0.01 compared to scores in column 3.