Fig. 6.

Identification of hsa-miR-204-5p as a potential miRNA upstream of SOX4 in hepatocellular carcinoma (HCC). (A) The miRNA/SOX4 regulatory network. (B) Correlation of predicted miRNA expression and SOX4 expression in HCC, analyzed using the R software package ‘ggstatsplot’ with a dataset comprised of mRNA-seq data for HCC from The Cancer Genome Atlas. (C–E) Expression of hsa-miR-5139 (C), hsa-miR-6730 (D), and hsa-miR-204-5p (E) in HCC and control normal samples, determined using the UALCAN database. (F–H) Expression of hsa-miR-6730 (F), hsa-miR-5139 (G), and hsa-miR-204-5p (H) in normal tissues and cancers with nodal metastasis status or nodal metastasis status, as determined using the UALCAN database. (I) The prognostic significance of high or low hsa-miR-204 expression in HCC was analyzed using the Kaplan–Meier plotter database. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, NC: not significant