Table 3.
Clinical parameters associated with normally converted ADP-induced platelet inhibition rate
| Variables | Univariate | Multivariate (stepwise elimination) | |||||
|---|---|---|---|---|---|---|---|
| Estimate, 95% CI | SEM | P value | Estimate, 95% CI | SEM | P value | ||
| Age | 0.042 (0.019,0.064) | 0.011 | < 0.001 | ||||
| Male | − 0.801 (− 1.461, − 1.141) | 0.335 | 0.018 | ||||
| Smoking | − 0.282 (− 0.808,0.245) | 0.267 | 0.293 | ||||
| LVEF, % | − 0.009 (− 0.041,0.022) | 0.016 | 0.555 | ||||
| Hypertension | 0.133 (− 0.433,0.699) | 0.287 | 0.645 | ||||
| Diabetes mellitus | 0.417 (− 0.118,0.952) | 0.271 | 0.126 | ||||
| Leukocyte count | − 0.056 (− 0.111,0.001) | 0.028 | 0.052 | − 0.059 (− 0.104, − 0.014) | 0.023 | 0.01 | |
| Neutrophil | − 0.069 (− 0.158,0.019) | 0.045 | 0.125 | ||||
| Hemoglobin | − 0.024 (− 0.039, − 0.008) | 0.008 | 0.003 | ||||
| Platelet | − 0.003 (− 0.008,0.002) | 0.003 | 0.31 | ||||
| MPV | − 0.066 (− 0.248,0.115) | 0.092 | 0.472 | ||||
| BUN | − 0.001 (− 0.082,0.081) | 0.041 | 0.998 | ||||
| Serum creatinine | 0.003 (− 0.003,0.009) | 0.003 | 0.306 | ||||
| Uric acid | 0.001 (− 0.003,0.002) | 0.001 | 0.745 | ||||
| ALT | − 0.006 (− 0.014,0.001) | 0.004 | 0.105 | ||||
| TC | − 0.160 (− 0.362, 0.041) | 0.102 | 0.118 | ||||
| Triglyceride | − 0.288 (− 0.633,0.057) | 0.175 | 0.101 | ||||
| HDL-C | − 0.228 (− 1.449,1.994) | 0.619 | 0.714 | ||||
| LDL-C | − 0.222 (− 0.494,0.051) | 0.138 | 0.11 | ||||
| Apolipoprotein A | − 0.203 (− 1.373,0.968) | 0.594 | 0.733 | ||||
| Glucose | 0.008 (− 0.096,0.113) | 0.053 | 0.875 | ||||
| Hs-CRP | − 0.002 (− 0.009,0.005) | 0.004 | 0.564 | ||||
| HbA1c | 0.123 (− 0.055,0.301) | 0.090 | 0.175 | ||||
| STEMI | − 0.316 (− 0.868,0.236) | 0.280 | 0.261 | ||||
| Thrombus aspiration | − 1.325 (− 1.821, − 0.829) | 0.252 | < 0.001 | − 0.94 (− 1.428, − 0.453) | 0.247 | < 0.001 | |
| Aspirin + ticagrelor | − 1.814 (− 2.369, − 1.258) | 0.282 | < 0.001 | − 1.497 (− 2.058, -0.936) | 0.285 | < 0.001 | |
| High thrombus | − 1.069 ( − 2.293, 0.154) | 0.62 | 0.086 | ||||
Multivariable regression analyses were conducted with adjustments for variables that demonstrated significance (P < 0.1) in univariable analysis, including age, gender, baseline hemoglobin level, leukocyte count, thrombus aspiration, high thrombus and the combination of aspirin and ticagrelor
ADP adenosine diphosphate, ALT alanine transaminase, BUN blood urea nitrogen, HbA1c glycosylated haemoglobin, HDL-C high-density lipoprotein cholesterol, Hs-CRP high sensitivity-C reactive protein, LDL-C low-density lipoprotein cholesterol, LVEF left ventricular ejection fraction, MPV mean platelet volume, STEMI ST-elevation myocardial infarction, TC total cholesterol