Table 4.
Most significantly different metabolite ratios in erythrocytes from patients with vs without SDHx PVs
| Parametera | P valueb | AUC of ROC curvec |
|---|---|---|
| Lactate/Ketoglutarate | <.0001 | 0.968 (0.899, 1.037) |
| Lactate/2HG | <.0001 | 0.968 (0.899, 1.037) |
| Lactate/Cis-aconitate | <.0001 | 0.962 (0.887, 1.037) |
| Lactate/Fumarate | <.0001 | 0.936 (0.840, 1.032) |
| 2HG/Asparagine | <.0001 | 0.923 (0.818, 1.028) |
| Asparagine/Fumarate | <.0001 | 0.923 (0.818, 1.028) |
| Lactate/Malate | .0001 | 0.910 (0.798, 1022) |
| 2HG/Glutamine | .0002 | 0.910 (0.798, 1022) |
| 2HG/Succinate | .0002 | 0.910 (0.798, 1022) |
| Fumarate | .0002 | 0.878 (0.750, 1006) |
| Lactate | .0018 | 0.840 (0.696, 0.984) |
Abbreviations: 2HG, 2-hydroxyglutarate; AUC, area under the curve, PV, pathogenic variant; ROC, receiver operator characteristic.
a Only most significant metabolite ratios with AUC > 0.9 are listed.
b Likelihood ratio test.
c 95% CIs in parentheses.