Table 5.

Diagnostic performance of metabolite ratios in plasma and erythrocytes to identify patients with SDHx PVs

Parameter	AUC of ROC curve	Specificity	Sensitivity
EDTA-Succinate/Fumarate	0.929	92% (11/12)	92% (12/13)
Erythrocyte-Lactate/Ketoglutarate	0.968	92% (11/12)	92% (12/13)
Combined	0.955	100% (12/12)	92% (12/13)

Specificity/sensitivity were calculated based on the Youden index of ROC curves.

Abbreviations: AUC, area under the curve, PV, pathogenic variant; ROC, receiver operator characteristic.