Fig. 3. Loss of astrocytic ANGPTL4 impairs body weight gain during chronic exposure to HFD.

(A) Body weight gain, (B) daily food intake, (C) food intake adjusted to the body weight, and (D and E) energy expenditure (EE) of Angptl4^GFAP mice and their controls during HFD intervention. (F) Glucose tolerance test (GTT) and area under curve (AUC) and (G) insulin tolerance test (ITT) and AUC in Angptl4^GFAP mice and their controls during HFD feeding (n = 8 and 7 mice per group, respectively). Data are presented as means ± SEM. *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001 as determined by two-tailed t test.