Fig. 6. Loss of astrocytic PPARγ exacerbates the metabolic susceptibility to chronic exposure to HFD.

(A) Body weight gain, (B) food intake (n = 7 and 11 mice per group, respectively), (C) food intake adjusted to body weight, (D and E) energy expenditure, and (F) physical activity of Ppar^GFAP mice and their controls during HFD intervention (n = 4 or 6 per group, respectively). (G) GTT and (H) ITT in Ppar^GFAP mice and their controls during HFD feeding (n > 4 mice per group). Data are presented as means ± SEM. *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001 as determined by two-tailed t test or Kolmogorov-Smirnov test for analyses of cumulative distribution.