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. 2024 Jul 16;15(8):e01718-24. doi: 10.1128/mbio.01718-24

Fig 10.

Diagram depicts metabolic pathways for DC-A degradation to vanillin and 5-FF in N. aromaticivorans and Sphingobium sp. SYK-6. Phylogenetic tree of Sphingomonadales indicates the presence of key enzymes across different bacterial strains.

Order Sphingomonadales contains two pathways for conversion of DC-C to DC-S-C and a conserved pathway for DC-S-C catabolism. Phylogeny constructed based on the bacterial reference genes of Alphaproteobacteria containing homologs (>50% amino acid identity, >70% query coverage) of at least two enzymes found in the β-5 linked aromatic catabolic pathways characterized in N. aromaticivorans or Sphingobium sp. SYK-6. Homologs found in each species are marked by colored boxes. Clades are labeled and color-coded. The scale bar indicates the number of nucleotide substitutions per sequence site. The gap in the outgroup corresponds to 1.5 on the scale bar. A simplified diagram of the DC-A catabolic pathways in N. aromaticivorans and Sphingobium sp. SYK-6 is shown.