Fig 2.

M. abscessus burden in the lungs of mice infected with isolates ATCC 19977 (A), M9501 (B), and M9530 (C). Time point week −1 represents 24 h after infection with M. abscessus via the aerosol route. Time point week 0 represents 1 week after infection and the day of treatment initiation. Time points weeks 1, 2, and 4 represent the end of 1, 2, and 4 weeks of treatment with once-daily 1× PBS (PBS), twice-daily 100 mg/kg subcutaneous imipenem (IMI), once-daily 25 mg/kg oral EBO (EBO25), or once-daily 50 mg/kg oral EBO (EBO50). Mean Mab burden in the lungs and standard error are shown (per group per time point, n = 5 at weeks −1, 0, + 1, and +2, and n = 10 at week +4).