Fig 3.

M. abscessus burden in the lungs of mice infected with isolate M9501. Time point week −1 represents 24 h after infection. Time point week 0 represents 1 week after infection and the day on which treatments were initiated. Time points weeks 1 and 4 represent the end of 1 and 4 weeks of treatment with once-daily 1× PBS (PBS), twice-daily 100 mg/kg intravenous imipenem (IMI), once-daily oral EBO at doses 0.5 mg/kg (EBO-0.5), 5 mg/kg (EBO-5), 10 mg/kg (EBO-10), 25 mg/kg (EBO-25), or 100 mg/kg (EBO-100). Mean Mab burden in the lungs and standard error are shown (per group per time point, n = 5 at weeks −1, 0, and +1, and n = 10 at week +4).