TABLE 2.

PK parameters in C3HeB/FeJ mice of epetraborole administered via oral gavage

Epetraborole dose (mg/kg)	Cmax (μg/mL)a	Tmax (h)b	T1/2 (h)c	AUClast (h*μg/mL)d
10	0.42	0.5	nde	2.70
50	4.16	0.5	1.92	13.8
100	13.7	0.5	1.55	31.7
200	21.0	0.5	1.70	46.7
300	33.3	0.5	1.99	76.4

^a C_max: maximum concentration of epetraborole in plasma.

^b T_max: time required for epetraborole concentration to reach its maximum.

^c T_1/2: half-life of epetraborole in plasma.

^d AUC_last: Area under the curve up to the last time point.

^e nd: not determined.