Log P values and other calculated physicochemical parameters using SwissADME for the synthesized compounds.

Compounds	Log P (mean ± % rsd)	H-bonds	PSA (Å2)
CA1 (MW = 346 g mol−1)	2.25 ± 0.03	H-donors = 1	90.02
		H-acceptors = 5
CA2 (MW = 362.34 g mol−1)	2.02 ± 0.08	H-donors = 2	110.25
		H-acceptors = 6
CA3 (MW = 405.36 g mol−1)	1.90 ± 0.04	H-donors = 1	135.84
		H-acceptors = 7
CA4 (MW = 392.36 g mol−1)	1.95 ± 0.03	H-donors = 2	119.48
		H-acceptors = 7
CA5 (MW = 418.40 g mol−1)	2.65 ± 0.03	H-donors = 2	119.48
		H-acceptors = 7
CE1 (MW = 347.32 g mol−1)	2.38 ± 0.05	H-donors = 0	87.22
		H-acceptors = 6
CE2 (MW = 363.32 g mol−1)	2.65 ± 0.07	H-donors = 1	107.45
		H-acceptors = 7
CE3 (MW = 406.35 g mol−1)	2.41 ± 0.06	H-donors = 0	133.04
		H-acceptors = 8
CE4 (MW = 393.35 g mol−1)	2.61 ± 0.06	H-donors = 1	116.68
		H-acceptors = 8
CE5 (MW = 419.39 g mol−1)	2.64 ± 0.10	H-donors = 1	116.68
		H-acceptors = 8
PA1 (MW = 370.40 g mol−1)	4.21 ± 0.06	H-donors = 1	69.04
		H-acceptors = 4
PA2 (MW = 386.40 g mol−1)	NDa	H-donors = 2	89.27
		H-acceptors = 5
PA3 (MW = 420.43 g mol−1)	3.76 ± 0.25	H-donors = 1	114.86
		H-acceptors = 6
PA4 (MW = 416.43 g mol−1)	4.26 ± 0.07	H-donors = 2	98.50
		H-acceptors = 6
PA5 (MW = 442.47 g mol−1)	4.44 ± 0.08	H-donors = 2	98.5
		H-acceptors = 6
PE1 (MW = 371.39 g mol−1)	5.19 ± 0.25	H-donors = 0	66.24
		H-acceptors = 5
PE2 (MW = 387.39 g mol−1)	5.18 ± 0.29	H-donors = 1	86.47
		H-acceptors = 6
PE3 (MW = 430.41 g mol−1)	4.29 ± 1.35	H-donors = 0	112.06
		H-acceptors = 7
PE4 (MW = 417.41 g mol−1)	4.47 ± 0.16	H-donors = 1	95.70
		H-acceptors = 7
PE5 (MW = 443.45 g mol−1)	4.92 ± 0.12	H-donors = 1	95.70
		H-acceptors = 7

^aNot determined.