In silico pre-ADME prediction of synthesized thiazolidine-2,4-dione hybrids.
| Compound | No. of rotatable bonds | H-acceptors | H-donors | QP log Po/w | Percent human oral absorption | Lipinski |
|---|---|---|---|---|---|---|
| 9A | 9 | 6 | 0 | 5.713 | 89.32 | Yes, 0 |
| 9B | 9 | 6 | 0 | 6.168 | 91.198 | Yes, 1 |
| 9C | 10 | 8 | 0 | 4.915 | 57.075 | No, 2 |
| 9D | 10 | 8 | 0 | 5.125 | 46.454 | No, 2 |
| 9E | 9 | 6 | 0 | 6.22 | 79.348 | Yes, 1 |
| 9F | 9 | 6 | 0 | 4.68 | 96.235 | Yes, 0 |
| 9G | 8 | 6 | 0 | 4.613 | 96.01 | Yes, 0 |
| 9H | 9 | 8 | 0 | 3.904 | 67.382 | Yes, 0 |
| 9I | 9 | 7 | 0 | 5.956 | 77.79 | Yes, 1 |
| 11A | 4 | 5 | 1 | 2.077 | 72.878 | Yes, 0 |
| 11B | 4 | 5 | 1 | 2.573 | 75.807 | Yes, 0 |
| 11C | 4 | 5 | 1 | 2.648 | 76.247 | Yes, 0 |