Table 11. Reported cases of organ transplant-donor derived human ehrlichiosis (n = 7).
No. | Year of publication | Age of patient (years) | Sex of patient | Country of infection | Pre-existing medical conditions | Organ transplantation due to | Culprit transplant organ | Time between transplantation and onset of symptoms (days) | Diagnosis of human ehrlichiosis established by | Ehrlichia species | Antimicrobial therapy | Time between onset of fever and appropriate treatment (days) | Complications | Outcome | Ref. |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2014 | 57 | Female | USA | ESRD secondary to hypertension, HCV, GERD | ESRD | Kidney | 22 | PCR, serology | E. chaffeensis | Doxycycline | 5 | N.r. | N.r. | [18] |
2 | 2014 | 56 | Male | USA | HTN, HCV, sleep apnea, | HTN | Kidney | 25 | Serology | E. chaffeensis | Tigecycline | 12 | Renal failure, DIC, spontaneous hemorrhage | Survived | [18] |
3 | 2021 | 70 | Male | USA | ESRD from polycystic kidney disease | ESRD | Kidney | 17 | PCR, microscopy | E. chaffeensis | Doxycycline | 7 | HLH, seizure, E. coli septicemia, DVT, candida fungemia | Died | [17] |
4 | 2021 | 66 | Male | USA | ESRD due to DM2, nephrectomy for renal cell carcinoma, adult onset Still disease | ESRD, renal cell carcinoma | Kidney | 9 | PCR | E. chaffeensis | N.r. | N.r. | HLH, cardiac arrest | Died | [17] |
5 | 2021 | 5 | Male | USA | ESRD due to obstructive uropathy | ESRD | Kidney | 9 | PCR | N.r. | Doxycycline | 7 | N.r. | Survived | [17] |
6 | 2021 | 6 | Male | USA | ESRD due to obstructive uropathy | ESRD | Kidney | 9 | PCR | E. chaffeensis | Doxycycline | 9 | HLH | Survived | [17] |
7 | 2021 | 69 | Male | USA | HCV-related cirrhosis | HCV-related cirrhosis | Liver | 11 | PCR | N.r | Doxycycline | 1 | N.r. | Survived | [17] |
DIC, disseminated intravascular coagulopathy; DM2, diabetes mellitus type 2; E. coli, Escherichia coli; E. chaffeensis, Ehrlichia chaffeensis; ESRD, end-stage renal disease; DVT, deep vein thrombosis; GERD, gastroesophageal reflux disease; HCV, hepatitis C virus; HLH, hemophagocytic lymphohistiocytosis; HTN, hypertensive nephropathy; N.r., none/not reported; PCR, polymerase chain reaction; Ref., reference; USA, United States of America.