Table 17. Reported sequelae of human monocytotropic ehrlichiosis (n = 11).

No.	Year of publication	Age of patient (years)	Sex of patient	Country of infection	Pre-existing medical conditions	Immuno-suppressive treatment	Time between first symptoms and presentation to hospital/physician (days)	Antimicrobial treatment	Time between presentation to hospital and specific therapy (days)	Complications	Sequelae	Ref.
1	1990	35	Male	USA	N.r.	N.r.	2	Doxycycline	N.r.	N.r.	Failed to regain his previous vigor, short-term memory impairment, recurrent parietal headaches.	[106]
2	1990	66	Male	USA	N.r.	N.r.	7	Tetracycline	0	N.r.	Persistent weakness and aching across the chest and shoulders for two months.	[107]
3	1992	63	Female	USA	N.r.	N.r.	N.r.	Doxycycline	N.r.	Hemodynamic instability	Fine tremor of her upper extremities, anorexia and weakness that resolved after four weeks.	[108]
4	1992	9	Female	USA	N.r.	N.r.	14	Chloramphenicol	3	DIC	Muscle strength was diminished for eight weeks.	[109]
5	1998	47	Female	USA	N.r.	N.r.	10	Doxycycline	N.r.	Sepsis, gastrointestinal hemorrhage, seizure, multi-organ failure, pulmonary embolism,	Residual neurologic deficits including brachial plexopathy, autonomic dysfunction and memory impairment.	[110]
6	2000	7	Female	USA	N.r.	N.r.	7	Chloramphenicol	N.r	Hemodynamic instability, ARDS, ascites, peripheral edema, DIC	Residual neurologic signs including ataxia, lower limb clonus, symmetrical hand tremor, photophobia, cognitive deficits. Motor and reflex signs resolved within 1 week, cognitive and affect impairment persisted for 3 weeks.	[111]
7	2013	73	Female	USA	N.r.	N.r.	4	Doxycycline	N.r.	Myocarditis	Cardiac decompensation resolved over several days, ejection fraction of 70% on echocardiogram 10 weeks after admission.	[112]
8	2017	16	Male	Colombia	N.r.	N.r.	N.r.	Doxycycline	N.r.	Seizures	Seizures	[113]
9	2021	15	Male	USA	N.r.	N.r.	4	Doxycycline	N.r.	Meningoencephalitis, sepsis	Increased agitation, impulsivity and poor cognition persisted 45 days after onset of illness.	[114]
10	2022	61	Female	USA	Liver transplantation	Yes	14	Doxycycline	N.r.	HLH, encephalitis, AKI, cardiac arrest	Temporary outpatient dialysis required.	[81]
11	2023	67	Female	USA	Autoimmune hepatitis, liver cirrhosis	Yes	7	Doxycycline	0	HLH, septic shock	Relapse of severe thrombocytopenia a few weeks after admission.	[84]

ARDS, acute respiratory distress syndrome; AKI, acute kidney injury/kidney failure; DIC, disseminated intravascular coagulopathy; HLH, hemophagocytic lymphohistiocytosis; N.r., None/not reported; USA, United States of America.