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. 2023 Aug 8;18(8):1190–1201. doi: 10.1093/ecco-jcc/jjad133

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© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — CpG sites associated with change over time following anti-TNF treatment regardless of treatment outcome. A] Manhattan plot of CpG sites associated with change over time following anti-TNF treatment regardless of treatment outcome. The top 10 differentially methylated positions with annotations are labelled in the plot. The grey horizontal line represents the significant p-value threshold of 9 x 10^-8. B] Predicted beta values of the top 10 differentially methylated positions and its change over time following anti-TNF treatment. TNF, tumour necrosis factor.