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. 2023 Aug 8;18(8):1190–1201. doi: 10.1093/ecco-jcc/jjad133

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© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — CpG sites at baseline associated with anti-TNF drug concentration. A] Manhattan plot of CpG sites at baseline associated with anti-TNF drug concentration at week 14. The top 10 CpG sites with their associated gene annotations are labelled in brackets. The grey horizontal line represents the significant p-value threshold of 9 x 10^-8. B] Beta methylation values at baseline of the top 20 CpG sites associated with both anti-TNF drug concentration at week 14 and primary non-response. TNF, tumour necrosis factor.