Figure 4.

Coefficients of DMPs associated with anti-TNF drug concentration at week 14 and primary non-response. Coefficients represent the beta values of each CpG from linear mixed effects model to each outcome. Spearman’s rho correlation of the coefficients calculated for those that were associated with both anti-TNF drug concentration and primary non-response, and the remaining that were only significant to anti-TNF drug concentration. TNF, tumour necrosis factor; PNR, primary non-response; DMP, differentially methylated positions.