Table 2.
Top 10 differentially methylated positions associated with anti-TNF treatment over time.
| CpG | Chromosome | Position | Relation to island | Gene name | Gene group | Coefficient [per week] | p-value |
|---|---|---|---|---|---|---|---|
| cg11047325 | 17 | 76354934 | Island | SOCS3 | Body | 0.0008 | 1.91E-41 |
| cg17501210 | 6 | 166970252 | OpenSea | RPS6KA2 | Body | 0.0007 | 1.40E-38 |
| cg19748455 | 17 | 76274856 | OpenSea | LOC100996291 | TSS1500 | 0.0008 | 2.55E-37 |
| cg00840791 | 19 | 16453259 | OpenSea | 0.0011 | 1.02E-35 | ||
| cg12992827 | 3 | 101901234 | OpenSea | 0.0010 | 2.23E-33 | ||
| cg04051206 | 17 | 17750855 | OpenSea | TOM1L2 | 3’UTR | 0.0005 | 4.19E-31 |
| cg03546163 | 6 | 35654363 | N_Shore | FKBP5 | 5’UTR | 0.0012 | 4.87E-31 |
| cg01526748 | 3 | 191930926 | OpenSea | FGF12 | Body | -0.0005 | 1.97E-30 |
| cg13074526 | 17 | 76274743 | OpenSea | LOC100996291 | TSS200 | 0.0008 | 2.32E-30 |
| cg18608055 | 19 | 1130866 | OpenSea | SBNO2 | Body | 0.0008 | 4.57E-30 |
TNF, tumour necrosis factor.