Table 3.
Top 10 differentially methylated positions at baseline associated with anti-TNF drug concentration at week 14
| CpG | Chromosome | Position | Relation to island | Gene name | Gene group | Coefficient [per week] | p-value |
|---|---|---|---|---|---|---|---|
| cg23320029 | 3 | 171004750 | OpenSea | TNIK | Body | 0.0555 | 4.62E-15 |
| cg16500036 | 7 | 68983906 | OpenSea | -0.0409 | 1.61E-14 | ||
| cg18513344 | 3 | 195531298 | OpenSea | MUC4 | Body | 0.0299 | 4.90E-14 |
| cg21635197 | 6 | 135405808 | OpenSea | 0.0389 | 8.71E-13 | ||
| cg22870160 | 1 | 231830793 | OpenSea | DISC1 | Body | -0.0376 | 1.23E-12 |
| cg03403209 | 16 | 29666641 | OpenSea | -0.0247 | 1.51E-12 | ||
| cg07856599 | 1 | 227151843 | OpenSea | ADCK3 | Body | -0.0411 | 6.82E-12 |
| cg01950011 | 8 | 37396511 | OpenSea | -0.0213 | 8.00E-12 | ||
| cg27216853 | 2 | 10205672 | OpenSea | CYS1 | Body | -0.0371 | 8.79E-12 |
| cg02011576 | 3 | 38060265 | OpenSea | PLCD1 | Body | -0.0387 | 8.82E-12 |
TNF, tumour necrosis factor.