Table 1.

Comparison between Argonaute CLIP-seq methods and agoTRIBE

Method	Argonaute CLIP-seq	agoTRIBE
Starting input	Millions of cells	Down to single cells
Approach	Immunoprecipitation in lysed cells	Editing in living cells
Antibodies	Needed	Not needed
Specialized laboratory equipment	Needed	Not needed
Duration of protocol (excluding cell work)	>4 days	1.5–2.0 days
Exact miRNA binding positions	Available	Not available
Extra information	−	Provides RNA-seq data