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. 2024 May 18;98(9):3019–3034. doi: 10.1007/s00204-024-03787-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Overview of the potency of THTMT inhibitors on different THTMT TH uptake assays. Data for the MCT8 column was taken from Wagenaars et al. (2023). The calculated BMC20 value is given for each THTMT TH uptake assay, as well as a color graded range of BMC20 as shown in the figure legend. Compounds for which no inhibition below 20% was observed are marked in red. ND = no BMC20 value was determined, NR = no significant response observed, NT = not tested, CT = cytotoxic at BMC20 (color figure online)