Fig. 2.

Clinical implications of BCAT1 expression in lung cancer. a Comparison of BCAT1 gene expression in normal lung tissue and primary lung adenocarcinoma tumors (left) or in tumor tissues from non-relapsed- and relapsed lung cancer patients (right) in the GSE31210 dataset, which contains 226 patients with primary stage I-II lung adenocarcinomas and 20 normal lung tissues. b Relapse-free survival probability of two groups of lung cancer patients classified by BCAT1 median expression levels in the GSE31210 dataset. c Comparison of BCAT1 gene expression in tumors from TKI-sensitive- and TKI-resistant NSCLC patients in the GSE231938 dataset. d IHC staining of BCAT1 in lung cancer tissues, adjacent noncancerous tissues and osimertinib-resistant tumors (n = 4). Results are shown as representative images and quantitative graphs. *p < 0.05, ***p < 0.001. Data are expressed as the mean ± SD