Table 3.

Fourteen CHIP-associated genetic variants identified in 94 paired saliva and blood-derived DNA samples. Three variants fell below the VAF 0.02 threshold as indicated in bold.

GRCh genomic coordinates	Ref	Alt	Gene	HGVSc	HGVSp	Blood			Saliva
						DP	VD	VAF	DP	VD	VAF
2:25246163	T	A	DNMT3A	NM_022552.5:c.1426A > T	p.Arg476Ter	2107	137	0.07	1360	90	0.07
2:25241561	CAT	C	DNMT3A	NM_022552.5:c.2081_2082del	p.Ile695ProfsTer17	1073	95	0.09	1403	83	0.06
4:105272592	G	A	TET2	NM_001127208.3:c.4211_4214delinsAAT*	p.Arg1404GlnfsTer44	1388	71	0.05	1152	59	0.05
2:25247053	G	A	DNMT3A	NM_022552.5:c.1120C > T	p.Gln374Ter	1184	25	0.02	1386	48	0.04
2:25246747	G	GA	DNMT3A	NM_022552.5:c.1151_1152insT	p.Val386GlyfsTer7	1665	87	0.05	902	50	0.06
2:25241682	GC	G	DNMT3A	NM_022552.5:c.1961del	p.Gly654AlafsTer51	2139	45	0.02	1573	40	0.03
2:25247710	TC	T	DNMT3A	NM_022552.5:c.894del	p.Lys299AsnfsTer17	3416	105	0.03	3216	79	0.03
2:2548216	C	CA	DNMT3A	NM_022552.5:c.675_676insT	p.Ala226CysfsTer27	710	76	0.11	506	40	0.08
4:105276152	A	G	TET2	NM_001127208.3:c.5642A > G	p.His1881Arg	3123	212	0.07	2087	120	0.06
2:25240363	A	C	DNMT3A	NM_022552.5:c.2261 T > G	p.Leu754Arg	2225	64	0.03	2176	62	0.03
17:7673802	C	T	TP53	NM_000546.6:c.818G > A	p.Arg273His	2367	115	0.05	1734	75	0.04
2:25235726	A	G	DNMT3A	NM_022552.5:c.2578 T > C	p.Trp860Arg	1410	41	0.03	913	7	0.008
2:25244257	G	T	DNMT3A	NM_022552.5:c.1749C > A	p.Cys583Ter	1952	59	0.03	1273	17	0.013
17:7675217	T	C	TP53	NM_000546.6:c.395A > G	p.Lys132Arg	2334	48	0.02	1273	11	0.009

*Upon visual reassessment of the genomic alignment the variant nomenclature was adjusted.