Table 2.
Differentially (increased abundance-i and decreased abundance-ii) proteins for lateral hypothalamus (LH) and striatum (ST) for pairwise comparison, that is, cocaine versus saline (left panel) and methamphetamine (METH) versus saline (right panel)
| Protein accession | Protein name | t | Protein accession | Protein name | t |
|---|---|---|---|---|---|
| Lateral hypothalamus (LH) | |||||
| i) Top ten increased abundance cocaine versus saline | i) Top ten increased abundance METH versus saline | ||||
| P43024|CX6A1_MOUSE | Cytochrome c oxidase subunit 6A1, mitochondrial | 11.7 | P43024|CX6A1_MOUSE | Cytochrome c oxidase subunit 6A1, mitochondrial | 24.9 |
| P97450|ATP5J_MOUSE | ATP synthase-coupling factor 6, mitochondrial | 11.2 | Q7TQI3|OTUB1_MOUSE | Ubiquitin thioesterase OTUB1 | 17.2 |
| Q7TQI3|OTUB1_MOUSE | Ubiquitin thioesterase OTUB1 | 9.8 | P43274|H14_MOUSE | Histone H1.4 | 15.8 |
| Q3UIU2|NDUB6_MOUSE | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | 9.5 | O35658|C1QBP_MOUSE | Complement component 1 Q subcomponent-binding protein, mitochondrial | 13.3 |
| Q9CPQ1|COX6C_MOUSE | Cytochrome c oxidase subunit 6C | 9.4 | Q8CCT4|TCAL5_MOUSE | Transcription elongation factor A protein-like 5 | 11.7 |
| P02088|HBB1_MOUSE | Hemoglobin subunit beta-1 | 8.4 | Q9CQJ8|NDUB9_MOUSE | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | 11.3 |
| P43274|H14_MOUSE | Histone H1.4 | 8.5 | Q91WS0|CISD1_MOUSE | CDGSH iron-sulfur domain-containing protein 1 | 11.2 |
| Q9CQZ6|NDUB3_MOUSE | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | 8.4 | O55126|NIPS2_MOUSE | Protein NipSnap homolog 2 | 11.1 |
| O08749|DLDH_MOUSE | Dihydrolipoyl dehydrogenase, mitochondrial | 8.2 | Q3UIU2|NDUB6_MOUSE | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | 10.7 |
| Q9CQH3|NDUB5_MOUSE | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | 8.1 | Q8K1M6|DNM1L_MOUSE | Dynamin-1–like protein | 10.5 |
| ii) Top ten decreased abundance cocaine versus saline | ii) Top ten decreased abundance METH versus saline | ||||
| Q9JIA1|LGI1_MOUSE | Leucine-rich glioma-inactivated protein 1 | −10.6 | Q91VD9|NDUS1_MOUSE | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | −10.6 |
| P56695|WFS1_MOUSE | Wolframin | −9.2 | P04104|K2C1_MOUSE | Keratin, type II cytoskeletal 1 | −10.4 |
| Q80TL4|PHF24_MOUSE | PHD finger protein 24 | −7.7 | P16330|CN37_MOUSE | 2′,3′-cyclic-nucleotide 3′-phosphodiesterase | −9.9 |
| Q9DBG3|AP2B1_MOUSE | AP-2 complex subunit beta | −7.2 | P68372|TBB4B_MOUSE | Tubulin beta-4B chain | −9.5 |
| P11798|KCC2A_MOUSE | Calcium/calmodulin-dependent protein kinase type II subunit alpha | −6.8 | P17182|ENOA_MOUSE | Alpha-enolase | −9.1 |
| Q60829|PPR1B_MOUSE | Protein phosphatase 1 regulatory subunit 1B | −6.6 | P01831|THY1_MOUSE | Thy-1 membrane glycoprotein | −9.1 |
| Q9JME5|AP3B2_MOUSE | AP-3 complex subunit beta-2 | −6.2 | P18242|CATD_MOUSE | Cathepsin D | −8.1 |
| Q5SQX6|CYFP2_MOUSE | Cytoplasmic FMR1-interacting protein 2 | −5.8 | Q7TMM9|TBB2A_MOUSE | Tubulin beta-2A chain | −7.9 |
| Q62277|SYPH_MOUSE | Synaptophysin | −5.7 | P48962|ADT1_MOUSE | ADP/ATP translocase 1 | −7.6 |
| Q9Z1S5|SEPT3_MOUSE | Neuronal-specific septin-3 | −5.7 | P01942|HBA_MOUSE | Hemoglobin subunit alpha | −7.5 |
| Striatum (ST) | |||||
| i) Top ten increased abundance cocaine versus saline | i) Top ten increased abundance METH versus saline | ||||
| P60904|DNJC5_MOUSE | DnaJ homolog subfamily C member 5 | 28.9 | P60904|DNJC5_MOUSE | DnaJ homolog subfamily C member 5 | 30.4 |
| Q9WV98|TIM9_MOUSE | Mitochondrial import inner membrane translocase subunit Tim9 | 22.3 | Q9QZM0|UBQL2_MOUSE | Ubiquilin-2 | 28.1 |
| P63323|RS12_MOUSE | 40S ribosomal protein S12 | 21.5 | O70591|PFD2_MOUSE | Prefoldin subunit 2 | 24.9 |
| P01831|THY1_MOUSE | Thy-1 membrane glycoprotein | 20.8 | Q9WV98|TIM9_MOUSE | Mitochondrial import inner membrane translocase subunit Tim9 | 23.5 |
| Q9CWM4|PFD1_MOUSE | Prefoldin subunit 1 | 20.4 | Q9CWM4|PFD1_MOUSE | Prefoldin subunit 1 | 20.3 |
| P56212|ARP19_MOUSE | cAMP-regulated phosphoprotein 19 | 20.0 | P63323|RS12_MOUSE | 40S ribosomal protein S12 | 19.8 |
| O70591|PFD2_MOUSE | Prefoldin subunit 2 | 17.8 | P56212|ARP19_MOUSE | cAMP-regulated phosphoprotein 19 | 19.1 |
| Q9QZM0|UBQL2_MOUSE | Ubiquilin-2 | 17.5 | Q9D1X0|NOL3_MOUSE | Nucleolar protein 3 | 18.8 |
| Q8R317|UBQL1_MOUSE | Ubiquilin-1 | 17.1 | P55066|NCAN_MOUSE | Neurocan core protein | 18.7 |
| Q9D8Z2|TRIA1_MOUSE | TP53-regulated inhibitor of apoptosis 1 | 16.3 | P63158|HMGB1_MOUSE | High mobility group protein B1 | 17.8 |
| ii) Top ten decreased abundance cocaine versus saline | Top ten decreased abundance METH versus saline | ||||
| P60202|MYPR_MOUSE | Myelin proteolipid protein | −21.5 | Q9R1Q9|VAS1_MOUSE | V-type proton ATPase subunit S1 | −32.2 |
| P52480|KPYM_MOUSE | Pyruvate kinase PKM | −18.9 | Q9D6M3|GHC1_MOUSE | Mitochondrial glutamate carrier 1 | −23.5 |
| Q61885|MOG_MOUSE | Myelin-oligodendrocyte glycoprotein | −17.8 | Q9CQQ7|AT5F1_MOUSE | ATP synthase F(0) complex subunit B1, mitochondrial | −23.5 |
| P68368|TBA4A_MOUSE | Tubulin alpha-4A chain | −17.4 | P60202|MYPR_MOUSE | Myelin proteolipid protein | −20.4 |
| P63011|RAB3A_MOUSE | Ras-related protein Rab-3A | −16.3 | P63011|RAB3A_MOUSE | Ras-related protein Rab-3A | −19.1 |
| O08599|STXB1_MOUSE | Syntaxin-binding protein 1 | −15.8 | O08599|STXB1_MOUSE | Syntaxin-binding protein 1 | −18.9 |
| Q9D0K2|SCOT1_MOUSE | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | −15.6 | Q8VDN2|AT1A1_MOUSE | ATP synthase F(0) complex subunit B1, mitochondrial | −18.4 |
| O88569|ROA2_MOUSE | Heterogeneous nuclear ribonucleoproteins A2/B1 | −15.0 | P52480|KPYM_MOUSE | Pyruvate kinase PKM | −18.2 |
| P06151|LDHA_MOUSE | L-lactate dehydrogenase A chain | −14.7 | P62827|RAN_MOUSE | GTP-binding nuclear protein Ran | −17.6 |
| P62806|H4_MOUSE | Histone H4 | −14.5 | Q9DBG3|AP2B1_MOUSE | AP-2 complex subunit beta | −17.1 |
A negative t value represents the lower expression, while a positive t value represents the higher expression in the first group. t = t value, a value from the t test which is similar to the difference between the means of the two groups or the log of the fold change.