Table 4.
The effect of lipopolysaccharide injection on the relative expression of the following genes: growth hormone receptor (GHR), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 5B (STAT5B), janus kinase 2 (JAK2), suppressor of cytokine signaling 3 (SOCS3), sirtuin 1 (SIRT1), and fibroblast growth factor 21 (FGF21) at the liver level.
| Gene | Group | Time groups | |
|---|---|---|---|
| 3 h | 9 h | ||
| GHR | Control | 1 ± 0.08 | 1 ± 0.10 |
| p value | 0.0003 | 0.008 | |
| LPS | 0.47 ± 0.05↓ | 0.58 ± 0.06↓ | |
|
| |||
| IGF1 | Control | 1 ± 0.19 | 1 ± 0.12 |
| p value | 0.46 | 0.03 | |
| LPS | 0.87 ± 0.15− | 0.67 ± 0.08↓ | |
|
| |||
| STAT5B | Control | 1 ± 0.11 | 1 ± 0.09 |
| p value | 0.0007 | 0.04 | |
| LPS | 0.41 ± 0.03↓ | 0.18 ± 0.08↓ | |
|
| |||
| JAK2 | Control | 1 ± 0.08 | 1 ± 0.10 |
| p value | 0.0005 | 0.70 | |
| LPS | 2.16 ± 0.20↑ | 1.08 ± 0.14− | |
|
| |||
| SOCS3 | Control | 1 ± 0.16 | 1 ± 0.16 |
| p value | 0.006 | 0.00007 | |
| LPS | 1.99 ± 0.21↑ | 3.30 ± 0.28↑ | |
|
| |||
| SIRT1 | Control | 1 ± 0.03 | 1 ± 0.11 |
| p value | 0.0009 | 0.07 | |
| LPS | 0.61 ± 0.07↓ | 1.29 ± 0.12− | |
|
| |||
| FGF21 | Control | 1 ± 0.07 | 1 ± 0.19 |
| p value | 0.07 | 0.003 | |
| LPS | 0.81 ± 0.05− | 2.74 ± 0.37↑ | |
The results are presented in arbitrary units as the mean ± standard error of the mean (SEM) and results with p ≤ 0.05 were deemed statistically significant. Arrows indicate significant differences between the groups, while dashes indicate no effect.