Fig. 8. In colorectal cancer, JOSD1 forms a regulatory loop with the Hippo/YAP axis.

This relationship is hypothesized to involve JOSD1 regulating YAP signaling and establishing a positive feedback loop. Activation of JOSD1 is believed to advance colorectal cancer progression through its modulation of YAP K48-linked deubiquitinating, resulting in increased YAP activity. Furthermore, YAP has been shown to stimulate the expression of JOSD1, thereby establishing a mutual reinforcement between the two factors.