Table 2.

Multivariate analysis of molecular alterations and OS in patients with HGSC and ENOC.

Histotype	Feature	Category	No. patients	(events, %)	HR	(95% CI)	P	P int
HGSCa,b
	RB1
		Retained	3,453	(71.3)	1	[Reference]
		Loss	686	(61.1)	0.74	(0.66–0.83)	6.8 × 10−7
	RB1 and BRCA status
		RB1 retained & gBRCAwt	714	(76.3)	1	[Reference]		0.24
		RB1 loss & gBRCAwt	135	(60.7)	0.74	(0.57–0.96)	0.023
		RB1 retained & gBRCAvar	159	(67.9)	0.69	(0.55–0.86)	0.001
		RB1 loss & gBRCAvar	70	(42.9)	0.38	(0.25–0.58)	5.2 × 10−6
ENOCa
	RB1
		Retained	649	(22.7)	1	[Reference]
		Loss	28	(39.3)	2.17	(1.17–4.03)	0.014
	RB1 and p53
		RB1 retained & p53 normal	492	(17.5)	1	[Reference]		0.698
		RB1 retained & p53 abnormal	58	(36.2)	2.26	(1.38–3.71)	0.001
		RB1 loss & p53 normal	11	(27.3)	1.77	(0.56–5.65)	0.332
		RB1 loss & p53 abnormal	12	(58.3)	5.34	(2.43–11.8)	<0.001

Abbreviation: P_int, P for interaction.

^aAdjusted for stage and age at diagnosis.

^bStratified by study.