Table 1.

Patient clinicopathological background of NAC and PC-naïve_HrR+ cohort disaggregated by TP53 signature status.

	NAC cohort							PC-naïve_HrR+ cohort
	All (n = 407)		wt signature (n = 118)		mt signature (n = 289)			All (n = 322)		wt signature (n = 227)		mt signature (n = 95)
	n	%	n	%	n	%	P*	n	%	n	%	n	%	P*	P* NAC cohort vs. PC-naïve_HrR+ cohort
Age median (Range)	48 (24–70)		46 (30–68)		48 (24–70)		0.073	52 (27–69)		53 (29–69)		52 (27–69)		0.19	<0.0001
Menopausal status							0.26							1.00	<0.0001
Premenopausal	254	62.4	79	66.9	175	60.6		153	47.5	108	47.6	45	47.4
Postmenopausal	153	37.6	39	33.1	114	39.4		169	52.5	119	52.4	50	52.6
pT							0.22							0.7	<0.0001
T1	20	4.9	8	6.8	12	4.2		202	62.7	144	63.4	58	61.1
T2	336	82.6	99	83.9	237	82.0		119	37.0	82	36.1	37	38.9
T3	51	12.5	11	9.3	40	13.8		1	0.3	1	0.4	0	0.0
pN							0.51							0.40	<0.0001
N0	213	52.3	65	55.1	148	51.2		292	90.7	208	91.6	84	88.4
N1	194	47.7	53	44.9	140	48.4		30	9.3	19	8.4	11	11.6
ER							<0.0001							0.30	<0.0001
positive	277	68.1	110	93.2	167	57.8		321	99.7	227	100.0	94	98.9
negative	123	30.2	6	5.1	117	40.5		1	0.3	0	0.0	1	1.1
NA	7	1.7	2	1.7	5	1.7		0	0.0	0	0.0	0	0.0
PgR							<0.0001							0.0011	<0.0001
positive	219	53.8	96	81.4	123	42.6		271	84.2	201	88.5	70	73.7
negative	178	43.7	20	16.9	158	54.7		51	15.8	26	11.5	25	26.3
NA	10	2.5	2	1.7	8	2.8		0	0.0	0	0.0	0	0.0
HER2							<0.0001							0.0009	<0.0001
positive	75	18.4	6	5.1	69	23.9		8	2.5	1	0.4	7	7.4
negative	320	78.6	108	91.5	212	73.4		280	87.0	203	89.4	77	81.1
NA	12	2.9	4	3.4	8	2.8		34	10.6	23	10.1	11	11.6
Grade							<0.0001							<0.0001	<0.0001
1	64	15.7	45	38.1	19	6.6		205	63.7	176	77.5	29	30.5
2	183	45.0	55	46.6	128	44.3		94	29.2	50	22.0	44	46.3
3	121	29.7	7	5.9	114	39.4		23	7.1	1	0.4	22	23.2
NA	39	9.6	11	9.3	28	9.7		0	0.0	0	0.0	0	0.0
Ki-67							<0.0001							<0.0001	0.65
<10 %	239	58.7	87	73.7	152	52.6		178	55.3	152	67.0	26	27.4
≧10%	163	40.0	27	22.9	136	47.1		129	40.1	61	26.9	68	71.6
NA	5	1.2	4	3.4	1	0.3		15	4.7	14	6.2	1	1.1