Table 3.

Primary regression models for composite IS by treatment group

	Intent-to-Treat (ITT)				Modified Intent-to-Treat (mITT)				Median or more visits in the assigned group (M+)
GPNC vs IPNC	Unj. Estimate (95% CI)	p	Adj. Estimate (95% CI)	P	Unj. Estimate (95% CI)	p	Adj. Estimate (95% CI)	p	Unj. Estimate (95% CI)	p	Adj. Estimate (95% CI)	p
Composite IS second trimester	−0.05 (−0.60 – 0.50)	0.87	0.04 (−0.53 – 0.61)	0.89	−0.10 (−0.69 – 0.50)	0.75	−0.08 (−0.69 – 0.53)	0.80	−0.09 (−0.80 – 0.61)	0.79	−0.12 (−0.85 – 0.61)	0.75
Composite IS third trimester	0.49 (0.03 – 0.95)	0.04	0.44 (0.03 – 0.84)	0.04	0.51 (0.02 – 1.00)	0.04	0.45 (0.01 – 0.89)	0.04	0.16 (−0.45 – 0.77)	0.61	0.11 (−0.51 – 0.74)	0.72

^*controlled for age, BMI, smoking before pregnancy, GA at blood draw Bolded results indicate p<0.05