Fig. 1.

The overview of the study design and principles of the present MR analysis. GCP, DNAm-based granulocyte proportions; IEAA, intrinsic epigenetic age acceleration; PAI-1, DNAm-based plasminogen activator inhibitor-1 levels; AMD, age-related macular degeneration; DR, diabetic retinopathy; PACG, primary angle-closure glaucoma; POAG, primary open-angle glaucoma; RRD, rhegmatogenous retinal detachment; RVO, retinal vascular occlusion; ARC, age-related cataract; CCT, central corneal thickness; IOP, intraocular pressure; mRNFL, macular retinal nerve fiber layer thickness; VCDR, vertical cup-to-disk ratio