Fig. 3.

MR estimated the causal association between epigenetic age acceleration and glaucoma endophenotypes using the inverse-variance weighted method. GCP, DNAm-based granulocyte proportions; IEAA, intrinsic epigenetic age acceleration; PAI-1, DNAm-based plasminogen activator inhibitor-1 levels; CCT, central corneal thickness; IOP, intraocular pressure; mRNFL, macular retinal nerve fiber layer thickness; VCDR, vertical cup-to-disk ratio; 95% CI, 95% confidence interval; P < 0.05 was considered statistically significant