Table 5.
Mediation effect of central corneal thickness in the association between epigenetic age acceleration and glaucoma
| Exposure | Mediator | Outcome | Total effecta | Direct effectb | Mediation effect | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | PIVW | Beta | SE | PIVW | Effect | SE | Pmed | Proportion (%) | |||
| HannumAge | CCT | PACG | −0.080 | 0.038 | 0.035 | −0.003 | 0.043 | 0.941 | −0.0007 | 0.0023 | 0.382 | 0.88 |
| IEAA | CCT | POAG | 0.037 | 0.011 | 6.10E−04 | −0.033 | 0.015 | 0.029 | −0.0014 | 0.0011 | 0.104 | 3.78 |
PACG, primary angle-closure glaucoma; POAG, primary open-angle glaucoma; CCT, central corneal thickness; IEAA, intrinsic epigenetic age acceleration; IVW, inverse-variance weighted; Pmed was derived from Z score table. P < 0.05 was considered as statistically significant
a. The causal effects of epigenetic aging on glaucoma derived from univariable two-sample MR analyses
b. The causal effects of epigenetic aging on glaucoma derived from multivariable MR analyses