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[Preprint]. 2024 Aug 11:2024.08.10.24311686. [Version 1] doi: 10.1101/2024.08.10.24311686

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Figure 5. — A: The predicted brain age (BA) for pwMS is on average 4.20 years greater than their chronological age (CA). Significance level: *** p < 0.001. B: Correlation between predicted brain age and chronological age in individuals with MS. A representative axial MRI slice of two individuals with MS (age range 46–50 years) is shown on the right. The individual with a brain age of 69 years has a greater degree of brain parenchymal atrophy and ventricular enlargement.