Figure 6. Predicted brain age is similar in lesion filled and non-lesion filled images.

A: comparison of the predicted brain age from the original T1w MRI and after performing lesion filling in people with multiple sclerosis (pwMS) from the RADIEMS cohort (n = 162). The two values are strongly correlated (Spearman’s ρ = 0.99, p < 0.001), with a mean difference of 0.26 years (middle plot, solid golden line). B: Bland-Altman plot illustrating a strong correlation between brain age predictions from 3T and 7T MRI for pwMS in the LCL cohort (n = 47), with Spearman’s ρ = 0.99, p < 0.001, and a mean absolute error (MAE) of 1.5 years.