Figure 8. Brain age difference is associated with disability in pwMS.

Heatmap showing Spearman’s correlation coefficient between chronological age, brain age, brain age difference, and clinical measures for the LCL and RADIEMS cohorts. EDSS: Expanded Disability Status Scale; SDMT: Symbol Digit Modalities Test; 9HPT: Nine-Hole Peg Test; T25FW: Timed 25-Foot Walk. Significance level: * p < 0.05, ** p < 0.01, *** p < 0.001, all adjusted for multiple comparisons using the false discovery rate method. Asterisks in parentheses indicate significance after adjusting for age.