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[Preprint]. 2024 Aug 7:2024.08.06.24311497. [Version 1] doi: 10.1101/2024.08.06.24311497

Figure 2. Prevalence of M-CHIP and L-CHIP mutations.

Figure 2.

Prevalence of CHIP mutations in all IBD patients and controls across all ages (A), and within age cohorts ≤45 and >45 years (B). CHIP was more prevalent in IBD at older ages compared to younger ages (OR 3.19, 95% CI 1.71–5.97, p = 2.82E-04). Prevalence of M-CHIP (C) and L-CHIP (D) in all IBD patients and controls for age cohorts ≤45 and >45 years. Both M-CHIP and L-CHIP were more prevalent in older IBD patients compared to younger IBD patients (OR 3.82, 95% CI 1.75–8.35, p = 0.001 and OR 3.74, 95% CI 1.44–9.72, p = 0.007, respectively). Prevalence of M-CHIP (E) and L-CHIP (F) in CD, UC, and controls by age cohorts ≤45 and >45 years. M-CHIP was more prevalent at older ages in UC when compared to healthy controls (OR 2.27, 95% CI 1.0–5.20, p = 0.053) and CD (OR 2.91, 95% CI 1.12–7.53, p = 0.028).

Alt text: A figure with six panels of bar charts reporting the prevalence of M and L chip in IBD.