Figure 1. Evaluation of genetically diverse mouse strains for susceptibility to SARS-CoV-2 Beta variant infection in comparison to transgenic K18-hACE2 mice.
(a) Experimental schematic showing nine unique mice strains were infected with 1×105 PFU SARS-CoV-2 Beta VOC and assayed at 3 days post-infection (dpi) and 5 dpi for lung viral titer (n=8/strain per time point, 4 males, 4 female) as well as survival (n=20/strain, 10 males, 10 females). (b) Phylogenetic tree showing diverse mouse strains is shown, adapted from Morgan et al. (c-d) Female and male body weights were monitored daily for 14.5 days post-infection. Data are graphed as mean percent of initial body weight ± SEM. (e-f) Probability of survival is shown for each strain. (g) Lung viral titers at 3- and 7 days post-infection graphed as mean titer ± SD.