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. 2023 Oct 5;230(2):e405–e415. doi: 10.1093/infdis/jiad434

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© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Binding antibody response against gp120 and V1V2. Samples from the participants collected at (A) 2 weeks after the last vaccination (month 6.5) and (B) 6 months after the last vaccination (month 12) were tested against HIV1 subtype C 96ZM651 gp120, 1086 B2 gp120, and subtype C TV1 gp120. C, Month 6.5 and (D) month 12 samples were also tested against HIV1 subtype C 96ZM651 gp70 V1V2, 1086 B2 gp70, and subtype C TV1 GSK gp70 V1V2. Graphs show (A) nonparametric AUTC and (B–D) net MFI. Numbers above indicate responders/total and percent. The median and boxplots (which display the first and third quartiles, whiskers indicate variability) are based on positive responders only (shown as filled circles); negative responders (below background) are shown as open symbols. Treatment groups are 200 µg Pr + MF59 (orange), 200 µg Pr + AS01_B, 40 µg Pr + AS01_B, and placebo. Abbreviations: AUTC, area under the baseline subtracted curve; gp, glycoprotein; MFI, mean fluorescence intensity; Pr, protein.