Table 2.

MicroRNAs associated with specific chromosome abnormalities.

MicroRNA	Sample source	Karyotype association	Expression	Function	Target	Implication	Reference
MiR-150	Bone marrow	MDS with del(5q)	Upregulated	Role in erythropoiesis, megakaryopoiesis	MYB, BC200	Potential therapeutic target	(34)
MiR-125b	Bone marrow	t(2;11)(p21;q23)	Upregulated	Block the myelomonocytic differentiation		Potential therapeutic target	(64)
MiR-194	Bone marrow	Trisomy 1	Upregulated	Apoptosis	p53	Prognostic marker	(4)
MiR-595	Bone marrow	Chromosome 7 abnormalities	Downregulated	Cellular proliferation, apoptosis, and defective ribosomal biogenesis	RPL27A	Potential therapeutic target	(65)
miR-449a, miR-300, miR-210, miR-874, miR-589, miR-451 miR-223, miR-128b, miR-342	Bone marrow	MDS with del(5q)	Downregulated			Diagnostic markers	(66, 67)
miR-196b, miR-451, miR-98, miR-34a, miR-10a miR-10b, miR-126, miR-99b miR-130a, miR-199a, miR-125a, miR-125b	Bone marrow	MDS with del(5q)	Upregulated			Diagnostic markers	(66, 67)