Table 6.
Univariable and multivariable Cox regression analysis for prognostic factors of short-term conversion to DLB
| Univariate analysis variable (s) | HR (95% CI) | P value |
|---|---|---|
| Age at LP | 1.08 (1.01–1.16) | 0.024 |
| Female sex | 1.49 (0.57–3.87) | 0.412 |
| Mild cognitive impairment at LP | 6.52 (2.75–15.44) | <0.001 |
| Prodromal PD rate at LP | 1.05 (1.01–1.09) | 0.017 |
| Abnormal DAT-SPECT | 1.78 (0.74–4.25) | 0.197 |
| UPSIT-40 score | 0.89 (0.81–0.98) | 0.031 |
| AS positivity | 9.18 (1.22–68.7) | 0.031 |
| t-tau value | 1.00 (0.99–1.00) | 0.774 |
| p-tau/Aβ42 ratio | 1.46 (1.01–2.11) | 0.046 |
| A+ | 2.31 (0.99–5.36) | 0.050 |
| A+T+ | 1.02 (0.30–3.46) | 0.975 |
| Neurofilament light chain | 1.00 (0.99–1.00) | 0.187 |
| Multivariate analysis variable (s)a | HR (95% CI) | P value |
|---|---|---|
| Age | 0.97 (0.89–1.07) | 0.606 |
| Mild cognitive impairment at LP | 11.23 (3.06–41.21) | <0.0001 |
| UPSIT-40 score | 1.01 (0.89–1.15) | 0.835 |
| p-tau/Aβ42 ratio | 1.25 (0.67–2.37) | 0.482 |
| AS positivity | 9.40 (0.88–100.65) | 0.064 |
p values indicating statistically significant differences between groups are highlighted in bold.
LP lumbar puncture, PD Parkinson disease, AS α-synuclein, Aβ42 42 amino acid isoform of amyloid-beta, p-tau phosphorylated tau protein, A amyloid-beta; T tau; t-tau total tau protein.
aIn the multivariable analysis, the prodromal PD rate was not included since it accounts for other variables (i.e., age, etc.) that are already included in the model.