Table 7.
Univariable Cox regression analysis for prognostic factors of short-term conversion to PD
| Univariate analysis variable(s) | HR (95% CI) | P value |
|---|---|---|
| Age at LP | 1.03 (0.96–1.09) | 0.414 |
| Female sex | 1.70 (0.70–4.18) | 0.243 |
| Mild cognitive impairment at LP | 1.16 (0.46–2.94) | 0.749 |
| Prodromal PD rate at LP | 1.03 (1.00–1.06) | 0.034 |
| Abnormal DAT-SPECT | 4.35 (1.48–12.75) | 0.007 |
| UPSIT-40 score | 0.98 (0.90–1.08) | 0.642 |
| AS positivity | 2.95 (0.87–10.02) | 0.083 |
| t-tau value | 0.99 (0.99–1.00) | 0.071 |
| p-tau/Aβ42 ratio | 0.73 (0.35–1.55) | 0.422 |
| A+ | 0.97 (0.36–2.63) | 0.959 |
| A+T+ | 0.98 (0.29–3.32) | 0.973 |
| Neurofilament light chain | 0.99 (0.99–1.00) | 0.673 |
p values indicating statistically significant differences between groups are highlighted in bold.
LP lumbar puncture, PD Parkinson disease, AS α-synuclein, Aβ42 42 amino acid isoform of amyloid-beta, p-tau phosphorylated tau protein, A amyloid-beta, T tau, t-tau total tau protein.