Table 4.
Differences of clinical characteristics between PD patients with and without AS accumulation in the GI tract
| Characteristic | Patients with PD | p-value | |
|---|---|---|---|
| AS+ (N = 73) | AS− (N = 24) | ||
| Sex, no. (%) | |||
| Male | 45 (61.6) | 12 (50.0) | 0.315 |
| Female | 28 (38.4) | 12 (50.0) | |
| Age, mean (SD), yr | |||
| At surgery | 71.4 (6.7) | 69.7 (7.4) | 0.308 |
| At the final follow-up visit | 75.9 (6.5) | 75.4 (8.5) | 0.750 |
| At symptom onset | 66.4 (7.5) | 68.0 (8.8) | 0.410 |
| At diagnosis | 68.5 (7.9) | 69.0 (8.5) | 0.790 |
| Duration, mean (SD), yr | |||
| Onset to surgery | 4.9 (4.9) | 1.8 (4.1) | 0.005 |
| Onset to diagnosis | 2.0 (2.6) | 1.0 (1.0) | 0.006 |
| Onset to the final follow-up visit | 9.5 (4.5) | 7.4 (5.1) | 0.063 |
| Surgery to the final follow-up visit | 4.5 (3.4) | 5.7 (3.9) | 0.178 |
| Frequency of patients who underwent surgery before the symptom onset, No. (%) | 8 (11.0) | 4 (16.7) | 0.484 |
| HY stage at the year of surgery (available in 29 patients), No. (%) | |||
| 1 | 3 (4.1) | 1 (4.2) | 0.998 |
| 2 | 5 (6.8) | 2 (8.3) | |
| 2.5 | 7 (9.6) | 2 (8.3) | |
| 3 | 7 (9.6) | 2 (8.3) | |
| Surgical site, No. (%) | |||
| UGI (stomach + esophagus) | 46 (63.0) | 9 (37.5) | 0.029 |
| LGI (colon + rectum) | 27 (37.0) | 15 (62.5) | |
PD Parkinson’s disease, AS alpha-synuclein, HY Hoehn and Yahr, GI gastrointestinal, UGI upper GI, LGI tract lower GI tract.