TABLE 2.
Univariable and multivariable Cox regression analyses assessing the effect of clinical/treatment‐related variables on recurrence‐free survival (RFS).
| Models | Category | Univariable | Multivariable | ||
|---|---|---|---|---|---|
| A. Overall cohort (98 events in N = 218) | HR (95%CI) | P | HR (95% CI) | p | |
| Risk group | High vs. Intermediate (ref) | 1.39 (0.92, 2.09) | 0.120 | 1.77 (1.16, 2.71) | 0.008 |
| Number of tumours | ≥2 vs. 1 (ref) | 1.17 (0.75, 1.82) | 0.483 | ‐‐ | ‐‐ |
| Tumour size | ≥3 cm vs. <3 cm (ref) | 1.03 (0.68, 1.55) | 0.907 | ‐‐ | ‐‐ |
| Tumour focality | Multifocal vs. Unifocal (ref) | 1.31 (0.84, 2.06) | 0.232 | ‐‐ | ‐‐ |
| Re‐TURBT | Yes vs. No (ref) | 0.43 (0.26, 0.72) | 0.001 | 0.58 (0.34, 1,00) | 0.050 |
| Adjuvant Treatment | BCG/Chemo vs. None (ref) | 0.32 (0.21, 0.47) | <0.0001 | 0.33 (0.21, 0.51) | <0.0001 |
| B. BCG group (55 events in N = 162 treated with BCG) | HR (95%CI) | p | HR (95%CI) | p | |
|---|---|---|---|---|---|
| Risk group | High vs. Intermediate (ref) | 1.87 (1.02, 3.44) | 0.044 | 2.46 (1.32, 4.58) | 0.005 |
| Re‐TURBT | Yes vs. No (ref) | 0.45 (0.24, 0.83) | 0.010 | 0.45 (0.24, 0.82) | 0.009 |
| BCG modality | Induction + maintenance vs. Induction (ref) | 0.27 (0.14, 0.50) | <0.0001 | 0.22 (0.12, 0.43) | <0.0001 |
BCG: Bacillus Calmette–Guerin; Re: restaging; TURBT: transurethral resection of bladder tumour; MP: muscle present. HR: Hazard ratio of recurrence for comparing groups. CI: confidence interval. p: p‐value testing HR = 1 from Wald test.