Table 1.
Baseline population characteristics, according to the presence of CAD.
| Overall N = 712 |
CAD N = 127 |
No CAD N = 585 |
P Value |
|
|---|---|---|---|---|
| Age, y | 39 ± 4.83 | 40.5 ± 4.4 | 38.7 ± 4.9 | <0.001 |
| Male | 325 (45.6) | 83 (65.4) | 242 (41.4) | <0.001 |
| Race/ethnicity* | ||||
| Hispanic | 318 (44.7) | 50 (39.4) | 268 (45.8) | 0.221 |
| Non-Hispanic Asian | 28 (3.9) | 8 (6.3) | 20 (3.4) | 0.207 |
| Non-Hispanic Black | 153 (21.5) | 28 (22.0) | 125 (21.4) | 0.960 |
| Non-Hispanic White | 33 (4.6) | 13 (10.2) | 20 (3.4) | 0.002 |
| Cardiovascular risk factors | ||||
| BMI, kg/m2 | 31.57 ± 8.22 | 33.31 ± 7.89 | 31.16 ± 8.25 | 0.009 |
| Diabetes Mellitus | 81 (11.6) | 21 (16.7) | 60 (10.5) | 0.070 |
| Hypertension | 229 (32.8) | 56 (44.4) | 173 (30.2) | 0.003 |
| Hyperlipidemia | 186 (26.6) | 53 (42.1) | 133 (23.2) | <0.001 |
| Family History of CAD | 92 (13.8) | 33 (27.5) | 59 (10.8) | <0.001 |
| Smoking History | ||||
| Current | 108 (15.5) | 22 (18) | 86 (15.0) | 0.479 |
| Former | 110 (15.8) | 27 (22.1) | 83 (14.5) | 0.049 |
| Never | 478 (68.7) | 73 (59.8) | 405 (70.6) | 0.027 |
| Primary Presenting Symptom | ||||
| Cardiac Chest Pain | 303 (42.6) | 85 (66.9) | 218 (37.3) | <0.001 |
| Non Cardiac Chest Pain | 228 (32.0) | 18 (14.2) | 210 (35.9) | <0.001 |
| Dyspnea | 106 (14.9) | 31 (24.4) | 75 (12.8) | 0.001 |
| Others | 215 (30.2) | 27 (21.3) | 188 (32.1) | 0.021 |
| Pre-test Probability | <0.001 | |||
| Low | 625 (87.8) | 97 (76.4) | 528 (90.3) | |
| Intermediate | 87 (12.2) | 30 (23.6) | 57 (9.7) | |
| Baseline laboratory values | ||||
| Total Cholesterol, mg/dL | 182.59 ± 42.84 | 186.09 ± 44.32 | 181.51 ± 42.39 | 0.361 |
| HDL-C, mg/dL | 46.23 ± 11.83 | 43.03 ± 11.47 | 47.03 ± 11.79 | 0.003 |
| LDL-C, mg/dL | 111.50 ± 36.70 | 116.44 ± 38.92 | 110.25 ± 36.07 | 0.142 |
| Non-HDL-C, mg/dL | 134.15 ± 46.31 | 143.06 ± 42.902 | 130.12 ± 47.32 | 0.023 |
| Triglycerides, mg/dL | 131.78 ± 108.73 | 144.29 ± 95.00 | 128.61 ± 111.84 | 0.207 |
| HbA1c | 6.08 ± 1.46 | 6.08 ± 1.46 | NA | NA |
| Creatinine, mg/dL | 0.89 ± 0.55 | 1.01 ± 1.07 | 0.86 ± 0.31 | 0.008 |
| Baseline Statin | ||||
| Statin | 126 (17.8) | 27 (21.6) | 99 (17.0) | 0.269 |
| Epicardial Adipose Tissue on CCT | ||||
| Volume, mL | 59.73 ± 31.08 | 80.80 ± 36.00 | 55.16 ± 27.92 | <0.001 |
| Mean density, HU | −75.80 ± 5.61 | −76.31 ± 6.30 | −75.70 ± 5.45 | 0.266 |
| Quartile | <0.001 | |||
| I | 189 (26.5) | 13 (10.2) | 176 (30.1) | |
| II | 172 (24.2) | 22 (17.3) | 150 (25.6) | |
| III | 174 (24.4) | 22 (17.3) | 152 (26.0) | |
| IV | 177 (24.9) | 70 (55.1) | 107 (18.3) |
Values are presented as n (%); mean ± SD; median [IQR].
BMI, body mass index; CAD, coronary artery disease; CCTA, coronary computed tomography angiography; HbA1c, hemoglobin A1C; HDL-C, high-density lipoprotein cholesterol; HU, Hounsfield unit; LDL-C, low-density lipoprotein cholesterol.
⁎
Race/Ethnicity (n = 532).