Four Pillars of the Obesity Medicine Association. Optimal management of the multifactorial disease of obesity requires an integrated multifactorial approach regarding (a) nutrition therapy (e.g., avoidance of ultraprocessed, caloric dense foods); (b) physical activity (e.g., routine dynamic and resistance training), behavior modification (e.g., willingness to apply techniques that facilitate healthful change), and medical intervention (e.g., medications, bariatric procedures, and complication management).