Fig. 4.

AE regulates the composition and function of intestinal microbiota in the DSS-induced colitis in mice. A: Venn diagram illustrating the overlap of intestinal flora among three groups of mice: control, DSS, and AE-treated (50 mg/kg). The diagram demonstrates comparable species diversity across the groups, with a total of 594 bacterial communities identified. B: Abundance maps of phylum classification level depicting the predominant phyla observed in each group, including Firmicutes, Bacteroidetes, Saccharibacteria, Actinobacteria, and Proteobacteria. C: Abundance maps of species classification level illustrating the impact of AE treatment (50 mg/kg) on specific bacterial species. Notably, AE treatment (50 mg/kg) effectively suppresses the overgrowth of Acetatifactor muris induced by colitis, restoring its abundance to normal levels. Representative results from one out of three independent experiments.