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. 2024 Jul 22;10(15):e34932. doi: 10.1016/j.heliyon.2024.e34932

Fig. 5.

Fig. 5

AE activates the IL-4/IL-13 pathway in the DSS-induced colitis in mice. A:Bioinformatics analysis reveals 12 common targets of AE in colitis. B:Gene Ontology analysis illustrates functional annotations of the identified targets.C:RT-PCR analysis demonstrates the expression levels of IL-4 and IL-13 in intestinal tissues of mice before and after 50 mg/kg AE treatment.D:Mouse body weight changes following IL-4 intervention in DSS-induced colitis mice, indicative of AE-like alleviation of colitis-induced weight loss.E:H&E staining and histological scoring of colon tissue sections depict the protective effect of exogenous IL-4 on DSS-induced intestinal injury. Data are presented as mean ± SD, **P < 0.01 and ***P < 0.001: compared to control group; #P < 0.05 and ##P < 0.01: compared with DSS and pc-DNA-NC + AE group. Representative results from one out of three independent experiments.