Skip to main content
. 2024 Jul 20;10(15):e34991. doi: 10.1016/j.heliyon.2024.e34991

Fig. 4.

Fig. 4

Long-term analgesic effect of continuous Metformin treatment on PWT in BCP rats. (A) The schematic diagram showed the timeline of Metformin administration and behavioral test. (B) The PWT of BCP rats treated with Metformin (i.p., 200 mg/kg) at 14 days after transplantation was significantly increased, compared with the BCP rats injected with normal saline, it began at 4 h and lasted for up to 1 d after Metformin treatment (*P < 0.05, **P < 0.01 vs BCP + NS, n = 8, two-way ANOVA). (C) The schematic diagram showed the timeline of Metformin administration and behavioral test. (D) The PWT of BCP rats treated with Metformin from 8 to 14 days after transplantation was significantly increased, compared with the BCP rats injected with normal saline, it began at 4 h and lasted for up to 14 d after continuous Metformin treatment (*P < 0.05, **P < 0.01, ***P < 0.001 vs BCP + NS, n = 8, two-way ANOVA). (E) Body weight of Sham, BCP, BCP + NS, BCP + Metformin groups (*P < 0.05, **P < 0.01, ***P < 0.001, Sham vs BCP, n = 8, two-way ANOVA). (F) Blood glucose of Sham, BCP, BCP + NS, BCP + Metformin groups (**P < 0.01, ***P < 0.001, Sham vs BCP, #P < 0.05, BCP + NS vs BCP + Metformin, n = 8, two-way ANOVA).