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Working Model. Walker 256 tumor cell transplantation induced bone cancer pain, and upregulated TGFβ1, TGFβRI and TRPV1 expression in BCP rats. Metformin could reduce the mechanical allodynia of BCP rats, the analgesia might be mediated by TGFβ1-TGFβRⅠ-TRPV1 signaling pathway.
